Effects of several lipidosis-inducing drugs upon the area postrema and adjacent medullary nuclei of adult rats
Identifieur interne : 003838 ( Main/Exploration ); précédent : 003837; suivant : 003839Effects of several lipidosis-inducing drugs upon the area postrema and adjacent medullary nuclei of adult rats
Auteurs : Wolf Frisch [Allemagne] ; Renate Lüllmann-Rauch [Allemagne]Source :
- Acta Neuropathologica [ 0001-6322 ] ; 1980-01-01.
English descriptors
- KwdEn :
- Teeft :
- Acta, Acta neuropathol, Adult rats, Area postrema, Berl, Cell tissue, Central neurons, Chloroquine, Chlorphentermine, Chlorphentermine treatment, Circumventricular, Circumventricular organ, Dendrite, Drug distribution, General lipidosis, Generalized lipidosis, Inclusion, Inset, Lipidosis, Lipidotic inclusions, Lysosomal, Lysosomal storage, Lysosome, Medulla oblongata, Nerve cell bodies, Nerve cell perikarya, Nerve cells, Nervi, Neuronal perikarya, Neuropathol, Nucleus dorsalis nervi vagi, Nucleus gracilis, Nucleus nervi hypoglossi, Nucleus tractus solitarii, Perhexiline, Perikarya, Postrema, Present findings, Present study, Quinacrine, Rat, Suzuki.
Abstract
Summary: The present study is concerned with the question of whether or not amphiphilic drugs (chloroquine, quinacrine, perhexiline) that fail to induce general lipidosis in the central nervous system (CNS) of adult rats can produce lipidosis in a circumventricular organ (area postrema) not furnished with a blood-brain barrier. Chlorphentermine known to induce general lipidosis in CNS of adult rats served as reference compound. All drugs, when chronically applied in high oral doses, induced significant perikaryal lipidosis in the area postrema. In the adjacent nuclei (nucleus tractus solitarii, nucleus dorsalis nervi vagi, nucleus nervi hypoglossi, nucleus gracilis), only chlorphentermine caused generalized lipidosis, whereas the other drugs had either limited or no effects. The present findings strongly suggest that the exemption, of most regions of the CNS of adult rats, from lipidosis induced by chloroquine and others is due to hindered drug distribution across the blood-brain barrier, rather than being due to non-susceptibility of central neurons toward the lipidosis-inducing action of the drugs.
Url:
DOI: 10.1007/BF00705806
Affiliations:
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of several lipidosis-inducing drugs upon the area postrema and adjacent medullary nuclei of adult rats</title><author><name sortKey="Frisch, Wolf" sort="Frisch, Wolf" uniqKey="Frisch W" first="Wolf" last="Frisch">Wolf Frisch</name></author><author><name sortKey="Lullmann Rauch, Renate" sort="Lullmann Rauch, Renate" uniqKey="Lullmann Rauch R" first="Renate" last="Lüllmann-Rauch">Renate Lüllmann-Rauch</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:EF1AACD4B9C8ED804AFC66F534DFF48D769A864D</idno><date when="1980" year="1980">1980</date><idno type="doi">10.1007/BF00705806</idno><idno type="url">https://api.istex.fr/ark:/67375/1BB-HXL92T4B-T/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000430</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000430</idno><idno 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general lipidosis in the central nervous system (CNS) of adult rats can produce lipidosis in a circumventricular organ (area postrema) not furnished with a blood-brain barrier. Chlorphentermine known to induce general lipidosis in CNS of adult rats served as reference compound. All drugs, when chronically applied in high oral doses, induced significant perikaryal lipidosis in the area postrema. In the adjacent nuclei (nucleus tractus solitarii, nucleus dorsalis nervi vagi, nucleus nervi hypoglossi, nucleus gracilis), only chlorphentermine caused generalized lipidosis, whereas the other drugs had either limited or no effects. The present findings strongly suggest that the exemption, of most regions of the CNS of adult rats, from lipidosis induced by chloroquine and others is due to hindered drug distribution across the blood-brain barrier, rather than being due to non-susceptibility of central neurons toward the lipidosis-inducing action of the drugs.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Schleswig-Holstein</li></region><settlement><li>Kiel</li></settlement></list><tree><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Frisch, Wolf" sort="Frisch, Wolf" uniqKey="Frisch W" first="Wolf" last="Frisch">Wolf Frisch</name></region><name sortKey="Lullmann Rauch, Renate" sort="Lullmann Rauch, Renate" uniqKey="Lullmann Rauch R" first="Renate" last="Lüllmann-Rauch">Renate Lüllmann-Rauch</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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